It should run. Have you tried right clicking on the install file in your downloads directory, and choosing 'Run as Administrator'?
If not, see if v1.7.2 installs better. (It will almost certainly run better after it is installed).
There are lots of bugs in ADE2.0. Try replacing ADE2.0 with the older but more reliable v1.7.2. Version 1.7.2, it is a little difficult to find, available on Adobe site for Windows and for Mac. http://helpx.adobe.com/digital-editions/kb/cant-install-digital-editio ns.html The forum software is sometimes corrupting the link above. There shouldn't be a blank in 'editio ns.html'. The following redirects to the same page: http://tinyurl.com/diged172